US Brand: Rebetol
Indian (Generic) Brand: Ribavin
Manufacturing: Lupin
Active Substance: Ribavirin
Dosage: 100mg / 200mg
Form release: blister 4 caps
Shipping time: 9 – 14 days

Description

An antiviral agent. Quickly penetrates into the cell and acts within the infected cells. Ribavirin readily phosphorylated intracellularly to adenosine mono-, di- and triphosphate metabolite. Ribavirin triphosphate – a strong competitive inhibitor of inosine monophosphate dehydrogenase, RNA polymerase of influenza virus and guanylyl transferase messenger RNA, the latter appears the inhibition of messenger RNA coating shell. These diverse effects lead to a significant reduction in intracellular guanosine triphosphate, and suppression of the synthesis of viral RNA and protein. Ribavirin inhibits the replication of new virions that lowers the viral load, which selectively inhibits the synthesis of viral RNA without inhibiting RNA synthesis in the normally functioning cells. Most sensitive to ribavtrinu DNA viruses – herpes simplex virus group pox, Marek’s disease; RNA viruses – influenza viruses A, B, paramyxoviruses (parainfluenza, mumps, Newcastle disease), reoviruses, oncogenic RNA viruses. Insensitive ribavtrinu DNA viruses – Varicella zoster, pseudorabies virus, vaccinia natural; RNA viruses – enteroviruses, rhinoviruses, encephalitis virus Semliki Forest. Activity ribavrina detected against the virus of hepatitis C. Although the mechanism of action is not fully identified, it is assumed that the cumulative phosphorylation as ribavirin triphosphate competitively inhibits the formation of guanosine triphosphate, thereby reducing the synthesis of viral RNA. It is also believed that the mechanism of the synergistic action of ribavirin and interferon alpha against hepatitis C virus due to increased phosphorylation of ribavirin with interferon.

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