Indian (Generic) Brand: Bortenat
Manufacturing: Natco
Active Substance: X-Tane
Dosage: 2mg / 3.5mg
Form release: lyophilizate powder in bottle
Shipping time: 9 – 14 days



Pharmacological action – an antineoplastic. Reversibly inhibits the chymotrypsin-like activity of the proteasome 26S. Proteasome 26S – large protein complex that catalyzes the cleavage of essential proteins and regulate their intracellular concentrations. So-called “ubiquitin-proteasome pathway” plays an important role in regulating the level of specific proteins, thereby maintaining homeostasis in mammalian cells. By inhibiting the action of chymotrypsin-like proteasome 26S, bortezomib causes inhibition of proteolysis, leading to a complex signaling cascade inside the cells, disruption of normal cell homeostasis and possibly apoptosis. Experiments have demonstrated that bortezomib is cytotoxic to a large number of tumor cell types in vitro. It also inhibits the growth of tumors in non-clinical in vivo tumor models, including multiple myeloma.

Images of Medicine.

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